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KMID : 0370220090530020060
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Yakhak Hoeji
2009 Volume.53 No. 2 p.60 ~ p.68
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The Application of Chiral HPLC Columns for Enantiomer Separation of Chiral Drugs
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Lee Won-Jae
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Abstract
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In terms of chiral issue, two enantiomers of chiral drugs often differ significantly in their pharmacological, toxicological and pharmacokinetic profile. Chiral switches of racemic drugs have been redeveloped as single enantiomers. Several chiral resolution techniques in chirotechnology are introduced and the most used chiral HPLC chromatographic method among several chiral analysis techniques is described with its several advantages. Several types of chiral HPLC columns derived from their chiral selectors are discussed with their property and applications for enantiomer separation.
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KEYWORD
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chiral drug, chiral separation, chiral HPLC column, chromatography
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